Komet 1905 IV (1906 b)

Meta Web Search with KOMET

KOMET is a logic-based mediator system that was designed for the knowledge-based integration of heterogeneous information sources CJKS97]. One of the main challenges in using the numerous information sources in the World Wide Web is to cope with their heterogeneity. In this work we demonstrate how popular web search services like Yahoo and AltaVista can be combined in the framework of KOMET to ...

Dmd059121 1890..1905

Subcutaneous injection is an important route of administration for therapeutic proteins that provides several advantages over other modes of parenteral delivery. Despite extensive clinical use, the exact mechanism underlying subcutaneous absorption of proteins is not completely understood, and the accuracy of prediction of absorption of biotherapeutics in humans remains unsatisfactory. This rev...

Dmd053405 1906..1913

Carbinol [4,49-(hydroxymethylene)dibenzonitrile] is the main phase 1 metabolite of letrozole, a nonsteroidal aromatase inhibitor used for endocrine therapy in postmenopausal breast cancer. We elucidated the contribution of UDP-glucuronosyltransferase (UGT) isoforms on the glucuronidation of carbinol. Identification of UGT isoforms was performed using a panel of recombinant human UGT enzymes. Ki...

Pierre Curie, 1859–1906

The year 2006 marked 100 years since the death of Pierre Curie. It is therefore appropriate that we remember his life and his work, which was cut short by his untimely death from an accident on the Pont Neuf, Paris, on April 19, 1906. He had already accomplished much during his life, both before the discovery of radium with Marie Curie, in work co-authored with his brother Jacques on piezoelect...

Christian A. Herter, 1906